Establishing reference intervals in the coagulation laboratory

Laboratory Reference Intervals in Africa

Establishing pediatric reference intervals: a challenging task.

Defining pediatric reference intervals (RIs) is one of the most difficult tasks in our profession. The continuously changing physiology of growing children makes their laboratory values a moving target. To measure specific analytes in the pediatric age range, one has to consider the interindividual variation of not only the homeostatic set point but also the developmental stage of each individu...

Establishing reference intervals for clinical laboratory test results: is there a better way?

Reference intervals are essential for clinical laboratory test interpretation and patient care. Methods for estimating them are expensive, difficult to perform, often inaccurate, and nonreproducible. A computerized indirect Hoffmann method was studied for accuracy and reproducibility. The study used data collected retrospectively for 5 analytes without exclusions and filtering from a nationwide...

eJIFCC Special Issue on Laboratory Reference Intervals

Recent decades have witnessed a tremendous increase in the number of new diagnostic methods and the introduction of many emerging new biomarkers in clinical diagnostic laboratories. The utility of biomarkers as screening and diagnostic tools is limited by many factors, such as sensitivity, specificity and predictive values. Another critical factor, not always carefully considered, is the availa...

Pediatric reference intervals for seven common coagulation assays.

References 1. Maseri A. Inflammation, atherosclerosis, and ischemic events: exploring the hidden side of the moon. N Engl J Med 1997;336:1014–6. 2. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med 1993; 340:115–26. 3. Libby P, Ridker PM. Novel inflammatory markers of coronary risk: theory versus practice. Circulation 1999;100:1148–50. 4. Li J-J, Fang C-H. C-Reactive protein is not ...